Selenium nanoparticles inhibit the growth of HeLa and MDA-MB-231 cells through induction of S phase arrest
2012
Luo, Haiying | Wang, Feifei | Bai, Yan | Chen, Tianfeng | Zheng, Wenjie
In vitro antiproliferative effects of selenium nanoparticles (nanoSe⁰, 10–40μmol/L) on HeLa (human cervical carcinoma) cells and MDA-MB-231 (human breast carcinoma) cells were examined by optical microscopic inspection and MTT assay in the present study. The nanoSe⁰ effectively inhibited the growth of MDA-MB-231cells and HeLa cells in a dose-dependent manner. The morphology analysis with atomic force microscope showed that the HeLa cells treated with 10μmol/L nanoSe⁰ were rough and shrunken with truncated lamellipodia at terminal part of the cells. Flow cytometric analysis demonstrated that HeLa cells were arrested at S phase of the cell cycle after exposed to nanoSe⁰ (10μmol/L). Taken together, our results suggested that nanoSe⁰ may be more helpful in cancer chemoprevention as a potential anticancer drug.
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