Inhibitory effect of peptide prepared from corn gluten meal 7,12-dimethylbenz[a]anthracene-induced mammary tumor progression in rats
1997
Yamaguchi, M. | Takeuchi, M. | Ebihara, K.
The effect of a peptide prepared from corn gluten meal (CP) by proteolysis with alkaline protease on 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumor progression were investigated in female Sprague-Dawley rats. At 6 weeks of age, rats were allowed free access to one of the four diets, 20% casein (CAS), 15% casein + 5% CP (5-CP), 10% casein + 10% CP (10-CP) or 10% casein + 10% free amino acid mixture simulated CP (AA) for 10 weeks. Rats were given 5 mg DMBA in 0.5 ml corn oil by stomach tube at two times (day 7 and 21). Tumor incidence was significantly lower in the 10-CP group, but not in the 5-CP and AA groups, than the CAS group. Total number and total weight of tumors were greater in the CAS group compared with 5-CP, 10-CP or AA groups. No changes were observed in serum 17 beta estradiol concentrations among the three groups (CAS, 10-CP and AA).
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