Multicomponent Synthesis of Tetrahydroisoquinolines
2018
Zeng, Linwei | Huang, Bo | Shen, Yangyong | Cui, Sunliang
A multicomponent synthesis of tetrahydroisoquinolines from carboxylic acids, alkynyl ethers, and dihydroisoquinolines is described. This process features readily available starting materials, simple experimental procedures for achievement of molecule complexity, and structural diversity. The preliminary control experiment and crossover reaction provide important insight into the reaction mechanism. The formed tetrahydroisoquinolines could be transformed to an array of compounds.
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