Synthesis and evaluation of γ-lactam analogs of PGE₂ as EP4 and EP2/EP4 agonists
2012
Kambe, Tohru | Maruyama, Tōru | Nakai, Yoshihiko | Oida, Hiroji | Maruyama, Takayuki | Abe, Nobutaka | Nishiura, Akio | Nakai, Hisao | Toda, Masaaki
To identify topically effective EP4 agonists and EP2/EP4 dual agonists with excellent subtype selectivity, further optimization of the 16-phenyl ω-chain moiety of the γ-lactam 5-thia prostaglandin E analog and the 2-mercaptothiazole-4-carboxylic acid analog were undertaken. Rat in vivo evaluation of these newly identified compounds as their poly (lactide-co-glycolide) microsphere formulation, from which sustained release of the test compound is possible, led us to discover compounds that showed efficacy in a rat bone fracture healing model after its topical administration without serious influence on blood pressure and heart rate. A structure–activity relationship study is also presented.
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