Comparative performance evaluation and systematic screening of solvents in a range of Grignard reactions
2013
Kadam, Asha | Nguyen, Mylinh | Kopach, Michael | Richardson, Paul | Gallou, Fabrice | Wan, Zhao-Kui | Zhang, Wei
The solvent effect on the Grignard reaction of benzyl, aryl and heteroaromatic substrates has been systematically evaluated based on reaction efficiency, ease of subsequent work-up, safety and greenness. 2-Methyltetrahydrofuran (2-MeTHF), which can be derived from renewable resources, had at least an equal if not a superior overall process most notably in suppressing the Wurtz coupling by-product from the benzyl Grignard reactions. It is therefore a recommended alternative solvent to Et₂O and THF for the preparation of most Grignard reagents and their subsequent reactions.
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