Comparison of the effects of pentagastrin and meal-stimulated gastrin on plasma calcitonin in normal man
1978
Owyang, Chung | Heath, Hunter III. | Sizemore, Glen W. | Go, Vay Liang W.
Extract: The effects of exogenous pentagastrin and meal-stimulated gastrin on plasma immunoreactive calcitonin (iCT) were compared in various studies of 13 normal adult men. To determine the effects of endogenous gastrin upon peripheral iCT concentrations, serum immunoreactive gastrin (iG) and plasma iCT in four men were measured at frequent intervals for 240 minutes after ingestion of low (100 mg) and high (400 mg) calcium meals. The results suggest that increases of plasma iCT concentrations after administration of pentagastrin in man reflect pharmacologic phenomena. Postprandial gastrin secretion may be insufficient to affect peripheral iCT concentrations.
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