Aconitum C20‐diterpenoid Alkaloid Derivatives Regulate the Growth and Differentiation of Cord Blood Derived Human Hematopoietic Stem/Progenitor Cells
2012
Hazawa, Masaharu | Wada, Kōji | Kashiwakura, Ikuo
The pharmacological activity of Aconitum alkaloids depends on their fundamental structure. While C19‐norditerpenoid alkaloids present significant toxicity to the central nervous system, C20‐diterpenoid alkaloids have reduced toxicities. However, there is little information regarding the precise pharmacological properties of C20‐diterpenoid alkaloids. C20‐diterpenoid alkaloid derivatives have explicit structure–activity relationships targeting various tumor cells, which depend on the C11‐substrate. However, the present study showed that C6‐derivatives additively or synergistically sustained proliferation of CD34+ hematopoietic stem/progenitor cells derived from the placental/umbilical cord blood. It revealed that identical structures belonging to C20‐diterpenoid alkaloids surprisingly have opposing proliferative effects depending on the derivatization sites (C6 versus C11).
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