Efficient Synthesis of Flavanone Glucuronides
2009
Boumendjel, Ahcène | Blanc, Madeleine | Williamson, Gary | Barron, Denis
The first efficient synthesis of flavanone glucuronides as potential human metabolites is described. The synthetic strategy is based on acetyl protection, followed by a combination of chemical and enzymatic deprotection steps. As an example, the method is applied to a synthesis of 7,4'-di-O-methyleriodictyol 3'-O-β-d-glucuronide. The aglycone is a flavanone naturally present in tarragon spice (Artemisia dracunculus) as well as in various Chinese, Brazilian, and Malaysian medicinal plants.
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