Anti-diabetic potential of peptides: Future prospects as therapeutic agents
2017
Marya, | Khan, Haroon | Nabvi, Seyed Mohammad | Habtemariam, Solomon
Diabetes mellitus is a metabolic disorder in which the glucose level in blood exceeds beyond the normal level and its effective control is recognized as a global challenge for clinician. Persistent hyperglycemia leads to diabetes late complication and obviously account for a large number of morbidity and mortality worldwide. Numerous therapeutic options are available for the treatment of diabetes including insulin for type I and oral tablets for type II, but its effective management is still a dream. Several options are under investigation in various research laboratories for efficacious and safer agents. Of them, peptides are currently amongst the most widely investigated potential therapeutic agents whose design and optimal uses are under development. A number of natural and synthetic peptides were found with outstanding antidiabetic effect, mediated through diverse mechanisms. The applications of new emerging techniques and drug delivery systems further offer opportunities to achieve the desired target outcomes. We found some outstanding peptides in preclinical and clinical studies with better efficacy and safety profile. Further detail studies on these peptides may therefore lead to significant clinically useful antidiabetic agents.
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