Evaluation of genotoxicity and oxidative stress of aluminium oxide nanoparticles and its bulk form in Allium cepa
2016
De, Arpita | Chakrabarti, Manoswini | Ghosh, Ilika | Mukherjee, Anita
In the present study, we examined the effects of aluminium oxide nanoparticles (Al₂O₃ NPs) and bulk aluminium oxide (Al₂O₃) on Allium cepa in terms of genotoxicity and oxidative stress responses under in planta conditions. The concentrations ranged from 1.25 to 5 µM for NP and its bulk form. Results from this investigation indicated steady rise in chromosome aberrations, micronuclei and DNA strand breaks with increase in concentration of the NPs, effects of Al₂O₃ NPs being significantly higher than those treated with bulk Al₂O₃. The divisional frequency was affected by the NP treatment. Oxidative damage such as lipid peroxidation and cell death to Allium under Al₂O₃ NPs treatments was greater than that observed in bulk Al₂O₃. A significant increase in activity of guiacol peroxidase was observed in accordance with the depletion in catalase activity in both Al₂O₃ NPs and bulk Al₂O₃ treated plants as compared to control. In conclusion, the present study indicated that Al₂O₃ NPs treatment exerted higher genotoxicity and oxidative stress responses on A. cepa than bulk Al₂O₃ under in planta conditions.
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