Effect of induction of histidase on histidine metabolism in vivo
1979
Kang-Lee, Young Ae | Harper, Alfred E.
Extract: The relationship between liver histidase activity and histidine catabolism was studied in rats fed L-amino acid diets containing 0.1, 0.25, 0.6, 1.2, or 3.0 percent of L-histidine, after they had been fed either 15 or 80 percent casein diets to induce different levels of liver histidase. The results suggest that with low dietary levels of histidine, histidine concentration is the major factor regulating histidine metabolism but with high dietary levels of histidine, histidase content becomes important for catabolism of excess histidine and maintenance of low tissue histidine concentration.
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