Dermal absorption and metabolism of xenobiotics in food-processing animals
1992
Riviere, J.E.
Dermal absorption of agricultural chemicals and animal drugs in food-producing animals must be considered as a potential route from which tissue residues of drugs and chemicals may occur. This has been supported in studies of topical pesticide exposure in cows and sheep. Despite the many advances made in in vitro and in vivo techniques for assessing percutaneous absorption in laboratory animals and man, very little systematic attention has been focussed on food-producing animals. The only exception is the pig since it is an accepted model for human studies. The purpose of this manuscript is to overview the literature on dermal xenobiotic absorption in food-producing animals to illustrate the risk that is present, and to outline how in vitro and in vivo methods could be applied to this problem. Factors which might alter dermal absorption and metabolism of xenobiotics will be presented. This work will hopefully provide a framework for the systematic investigation of comparative dermal absorption across the diverse species of food-producing animals.
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