A one-pot selective synthesis of N-Boc protected secondary amines: tandem direct reductive amination/N-Boc protection
2012
Neelarapu, Raghupathi | Petukhov, Pavel A.
A one-pot tandem direct reductive amination of aldehydes with primary amines resulting in N-Boc secondary amines using a (Boc)₂O/sodium triacetoxyborohydride (STAB) system is reported. The tandem procedure is efficient, selective, and versatile, giving excellent yields of N-Boc protected secondary amines even in those cases where the products are prone to intramolecular lactamization.
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