Effects of dietary trans N-3 polyunsaturated fatty acids on the rat electroretinogram
1998
Chardigny, J.M. | Bonhomme, B. | Sebedio, J.L. | Juaneda, P. | Vatele, J.M. | Doly, M. | Grandgirard, A.
Trans isomers of alpha linolenic acid are formed during heat treatment of vegetable oils. As a consequence, they are present in the human diet. Their effects on biological functions are not yet fully understood. In the present work, the effects of dietary trans n-3 fatty acids on the rat electroretinogram (ERG) were studied, as the retina is a tissue particularly rich in n-3 fatty acids. An isolated perfused rat retina model was used in order to monitor the b-wave of the ERG. A diet containing ethyl esters of trans alpha linolenic acid isomers or not (control) was given to Wistar male rats for 6 weeks. The incorporation of C22:6 delta 19 trans fatty acid was studied after this feeding period. Dietary trans isomers of n-3 fatty acids significantly altered the maximal b-wave amplitude of the isolated retina. The low trans isomers incorporation in the total retina lipids suggests that further studies are needed to clarify how dietary trans n-3 fatty acids may act.
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