Optimization of the QuEChERS method for multi-residue analysis of pharmaceuticals and pesticides in aquaculture products
2023
Kim, Kihwan | Choi, Younghun | Mok, Sori | Moon, Hyo-Bang | Jeon, Junho
The aim of study was to optimize an QuEChERS extraction procedure for simultaneous determination of organic pollutants in aquaculture products. The QuEChERS extracts were measured using LC-HRMS. The target contaminants include 32 pesticides and 20 pharmaceuticals which have not been regulated for the products in Korea. The method was validated according to CODEX guideline (CAC/GL 71–2009). LOD and LOQ for all analytes ranged from 0.1 to 2 μg/kg and from 0.5 to 5 μg/kg, respectively. Intra-day (n = 5) and inter-day (n = 9) accuracy and precision were evaluated with the guideline. The validated method was applied to aquaculture products (n = 303). As a result, 14 pesticides and 8 pharmaceuticals were quantified. Fluxapyroxad, a fungicide frequently detected in domestic surface waters, was found with relatively higher concentration in 17 out of 23 species. It proves that a hydrophobic inland contaminant can be accumulated in the aquaculture products.
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