A biocompatible process to prepare hyaluronan-based material able to self-assemble into stable nano-particles
2015
Calce, Enrica | Ringhieri, Paola | Mercurio, Flavia Anna | Leone, Marilisa | Bugatti, Valeria | Saviano, Michele | Vittoria, Vittoria | De Luca, Stefania
New self-assembled nano-particles were developed by chemical conjugation of natural fatty acids to the backbone of hyaluronan (HA). The chemical structure and the self-association behavior of them were studied by FT-IR, NMR, fluorescence and dynamic light scattering. The HA derivatives form stable spherical shape aggregates, as assessed by transmission electron microscopy.
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