Acyl-homoserine lactones suppresses IEC-6 cell proliferation and increase permeability of isolated rat colon
2014
Joe, Ga-Hyun | Andoh, Midori | Nomura, Mikako | Iwaya, Hitoshi | Lee, Jae-Sung | Shimizu, Hidehisa | Tsuji, Youhei | Maseda, Hideaki | Miyazaki, Hitoshi | Hara, Hiroshi | Ishizuka, Satoshi
We investigated to determine whether a variety of acyl-homoserine lactones (AHLs) influences epithelial cell proliferation and mucosal permeability. 3-Oxo-C₁₂-homoserine lactone (HSL) and 3-oxo-C₁₄-HSL significantly suppressed IEC-6 cell proliferation. A significant increase in mucosal permeability was observed in isolated rat colon tissue exposed to C₁₂-HSL, 3-oxo-C₁₂-HSL, and 3-oxo-C₁₄-HSL. These data indicate that AHLs suppress epithelial proliferation and disrupt barrier function in intestinal mucosa.
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