Influence of fish oil on blood lipids in coronary artery disease
1991
Nikkila, M.
The low incidence of coronary artery disease in Greenland Eskimos may be due to their intake of seafood with a high content of n-3 polyunsaturated fatty acids which may have a hypolipidaemic effect. Results of previous studies have been controversial, depending on the dosage of fish oil and the phenotypic cause of the hyperlipoproteinaemia. In this placebo-controlled, double-blind, cross-over study, patients (n = 32) with coronary artery disease and dyslipidaemia received firstly 2.4 g eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids. Thereafter in the open study the same study group received 3.6 g EPA/DHA. Fish oil had no significant effect on serum cholesterol or high density lipoprotein (HDL) cholesterol. Low doses of fish oil (2.4 g EPA/DHA) reduced serum triglyceride level significantly (P < 0.05) and more significantly (P < 0.01) with 3.6 g EPA/DHA. The results indicated that the therapeutic effect of n-3 fatty acids as hypolipidaemic agents is greatest in patients with severe hypertriglyceridaemia (> 3.00 mmol/l).
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