Endocrine effects of the GnRH antagonist, acyline, in domestic dogs
2009
García Romero, G. | Valiente, C. | Aquilano, D. | Corrada, Y. | Gobello, C.
Gonadotrophin-releasing hormone (GnRH) antagonists may have a future role in the control of canine reproductive function. In this study, the effects of a single dose of the potent GnRH antagonist, acyline, on serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T) were evaluated in male dogs. Blood samples were drawn before (Day -1) and after (30, 60, and 90min, 3, 6, 9, 12, and 24h, and 3, 6, 9, 14, 22, and 29d) treatment with acyline (330μg/kg, sc); serum concentrations of FSH, LH, and T varied throughout the study period (P <0.01, <0.05, and <0.01, respectively). Gonadotrophins decreased below pretreatment concentrations 60min after injection, whereas T took 90min to decrease below baseline (P >0.05). Follicle-stimulating hormone, LH and T decreased until Day 9, when they reached their nadir at 2.0 ±1.1ng/mL (P <0.01), 1.2±0.2ng/mL (P >0.05), and 0.5±0.2ng/mL (P <0.05), respectively. Both gonadotrophins and T began increasing on Day 14 after treatment, although FSH and T serum concentrations still remained below baseline on that day (P >0.05). Follicle-stimulating hormone and T rebounded above baseline on Day 29, whereas LH reached concentrations were similar to baseline at this time (P >0.05). No local or systemic side effects were detected in any dog following acyline treatment. In conclusion, a single acyline treatment safely and reversibly decreased serum gonadotrophin and T concentrations in dogs for 9d.
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