The effects of thiamine and EDTA on biliary and urinary lead excretion in sheep
1992
Olkowski, A.A. | Gooneratne, S.R. | Christensen, D.A.
Relative efficacy of thiamine (B1) and/or calcium disodium ethylinediaminetetraacetate (EDTA) administration on lead (Pb) excretion via bile and urine was studied in Pb-loaded sheep. The sheep were administered B1 s.c., 75 mg/kg body wt., EDTA i.v., 110 mg/kg body wt., and a combination of B1-EDTA at rates as above. Each treatment was followed by 69h sampling of blood, bile, and urine. Urinary Pb excretion increased following B1-EDTA > EDTA > B1 administration. Thiamine and B1-EDTA treatments increased biliary Pb excretion. Overall, B1, EDTA and B1-EDTA administration increased Pb excretion via bile and urine by 72%, 595%. and 842% respectively over basal level (mean +/- SE: 20.1 + 2.9 mug Pb/h). it has been concluded that thiamine enhances elimination of Pb from the body and this feature may be beneficial in chelation therapy.
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