Three new Lycopodium alkaloids from Huperzia carinata and Huperzia squarrosa
2014
Thorroad, Sakornrat | Worawittayanont, Prateep | Khunnawutmanotham, Nisachon | Chimnoi, Nitirat | Jumruksa, Apiwan | Ruchirawat, Somsak | Thasana, Nopporn
Eleven Lycopodium alkaloids with lycodine-type, lycopodine-type, and fawcettimine-related skeletons were isolated from the whole plants of Huperzia carinata (Desv. Ex. Poir.) Trevis and Huperzia squarrosa (G. Forst) Trevis (Huperziaceae). Among them, 8,15-dihydrohuperzine A (2), lycocarinatine A (3), and lycoposerramine U N-oxide (11) are new compounds. The structures of these new alkaloids were elucidated on the basis of 2D NMR correlations. Some of these isolated alkaloids were assayed for acetylcholinesterase (AChE) inhibitory activity.
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