Nutrient composition, antioxidant properties, and anti‐proliferative activity of Lignosus rhinocerus Cooke sclerotium
2013
Yap, Yeannie HY | Tan, NgetHong | Fung, ShinYee | Aziz, Azlina A | Tan, ChonSeng | Ng, SzuTing
Lignosus rhinocerus (tiger milk mushroom) is an important medicinal mushroom used in Southeast Asia and China, and its sclerotium can be developed into functional food/nutraceuticals. The nutrient composition, antioxidant properties, and anti-proliferative activity of wild type and a cultivated strain of L. rhinocerus sclerotia were investigated. The sclerotial powder has high carbohydrate but low fat content. Interestingly, the cultivated strain contains higher amounts of protein and water-soluble substances than the wild type. Phenolic content of hot-water, cold-water, and methanol extracts of the sclerotial powders ranged from 19.32 to 29.42 mg gallic acid equivalents g(-1) extract, while the ferric reducing antioxidant power values ranged from 0.006 to 0.016 mmol min(-1) g(-1) extract. The DPPH(•) , ABTS(•+) , and superoxide anion radical scavenging activities of the extracts ranged from 0.52 to 1.12, 0.05 to 0.20, and -0.98 to 11.23 mmol Trolox equivalents g(-1) extract, respectively. Both strains exhibited strong superoxide anion radical scavenging activity comparable to rutin. The cold-water extracts exhibited anti-proliferative activity against human breast carcinoma (MCF-7) cells, with IC50 values of 206 µg mL(-1) and 90 µg mL(-1) for the wild type and cultivated strains, respectively. The cultivated L. rhinocerus sclerotium has the potential to be developed into functional food/nutraceuticals. © 2013 Society of Chemical Industry.
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