Cytotoxic and anti-inflammatory activities of secondary metabolites from Ophiorrhiza baviensis growing in Thua Thien Hue, Vietnam
2021
Viet Cuong, Le Canh | Anh, Le Tuan | Huu Dat, Ton That | Anh, Tran Thi Phuong | Lien, Le Quynh | Kim, Young Ho | Tuan Anh, Hoang Le
A new ursane-type triterpene, 3β,23,24-trihydroxyurs-12-en-28-oic acid (1), together with eight known compounds (2–9) were isolated from the aerial parts of Ophiorrhiza baviensis. Among them, compounds 2–5 were found for the first time from the genus Ophiorrhiza, while compounds 6–9 were reported from O. baviensis for the first time. Their structures were elucidated by analysis of HR-ESI-MS and NMR (¹H-NMR, ¹³C-NMR, HSQC, and HMBC) spectra, as well as comparison with those reported in the literature. Moreover, all isolated compounds were evaluated for their cytotoxic activities against MCF-7, Hela, KB, A549, and SK-LU-1 cancer cell lines and their effects on LPS-induced NO production in RAW264.7 cells. This is the first report of chemical constituents and biological activities of O. baviensis.
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