Buckwheat concentrate reduces serum glucose in streptozotocin-diabetic rats
2003
Kawa, J.M. | Taylor, C.G. | Przybylski, R.
The antihyperglycemic effects of chemically synthesized D-chiro-inositol (D-CI), a component of an insulin mediator, have been demonstrated in rats. Buckwheat contains relatively high levels of D-CI: thus, it has been proposed as a source of D-CI for reducing serum glucose concentrations in diabetics. The present study evaluates the effects of a buckwheat concentrate, containing D-CI, on hyperglycemia and glucose tolerance in streptozotocin (STZ) rats. In fed STZ rats, both doses of the buckwheat concentrate (containing 10 and 20 mg of D-CI/kg of body weight) were effective for lowering serum glucose concentrations by 12-19% at 90 and 120 min after administration. Findings from this study demonstrate that a buckwheat concentrate is an effective source of D-CI for lowering serum glucose concentrations in rats and therefore may be useful in the treatment of diabetes.
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