Effect of acetylsalicylic acid on secondary metabolism of Catharanthus roseus tumor suspension cultures
1997
Godoy-Hernandez, G. | Loyola-Vargas, V.M.
Addition of various concentrations (0.5-20 mM) of acetylsalicylic acid (ASA) to tumor lines of Catharanthus roseus cultivated in vitro and requiring corn starch as carbon source, produced remarkable effects on secondary metabolite production. An increase of 505% total alkaloids per culture (cells plus liquid medium), 1587% total phenolics (liquid medium), 612% total furanocoumarins (liquid medium), and 1476% total anthocyanins (liquid medium) was detected. 1 mM ASA in combination with other elicitors, such as homogenates of Aspergillus fumigatus or trans-cinnamic acid, did not further increase the metabolite content substantially. The results suggest that ASA could act as a new biotic elicitor of metabolite production in C. roseus cell suspension culture.
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