Dibenzocyclooctadiene Lignans from Kadsura polysperma and Their Antineurodegenerative Activities
2012
Dong, Ke | Pu, Jian-Xin | Zhang, Hai-Yan | Du, Xue | Li, Xiao-Nian | Zou, Juan | Yang, Jian-Hong | Zhao, Wei | Tang, Xi-Can | Sun, Han-Dong
Eleven new dibenzocyclooctadiene lignans, polysperlignans A–K (1–11), and eight known analogues (12–19) were isolated from the stems of Kadsura polysperma. Their structures and absolute configurations were established using a combination of MS, NMR, CD, and single-crystal X-ray diffraction techniques. Selected compounds were evaluated for activity against β-amyloid- or hydrogen peroxide-induced neurotoxicity on PC12 cells, and 1, 2, 4, 5, 13, and 16 showed statistically significant neuroprotective effects in these in vitro assays.
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