Target-assisted self-cleavage DNAzyme probes for multicolor simultaneous imaging of tumor-related microRNAs with signal amplification
2019
Wan, Yuan-Hui | Zhou, Yu-Jie | Xiao, Ke-Jing | Nie, Cun-Peng | Zhang, Juan | Liu, Chang | Chen, Ting-Ting | Chu, Xia
In this work, we have developed a novel and highly selective signal amplification strategy based on target-assisted self-cleavage DNAzyme probes for multicolor and simultaneous imaging of miRNA-222 and miRNA-223 in living cells. The fluctuation of miRNA-222 and miRNA-223 expression levels could also be monitored.
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