In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines
2016
Krstić, P Milena | Borozan, Z Sunčica | Sovilj, P Sofija | Grgurić-Šipka, R Sanja | Oljarević, M Jelena
The purpose of the present study was to investigate and compare the effects of two ruthenium complexes with trifluoperazine on acethylcholinesterase enzyme activity and lactate dehydrogenase levels in vivo under physiological conditions in rats blood. Complexes 1 and 2 showed positive effects on acethylcholinesterase at all doses and did not disturb its normal activity. Total LDH activity was inhibited in the presence of both complexes, but Ru(II) complexes showed different effects on the activity of LDH isoenzymes. The activities of LDH₁ and LDH₂ isoenzymes were decreased in all applied doses of the complex 2, while the activity of LDH₂ reduced using complex 1 in the same doses. Results of the present study suggest the neuro- and cardio protective potential of oral administration of complexes 1 and 2, as non-toxic compounds under physiological conditions. These protective effects are the result of their potent antioxidant activity.
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