Role of NF-kB, p53, and p21 in the Regulation of TNF-α Mediated Apoptosis of Lymphocytes
2010
Ryazantseva, N. V | Novitskii, V. V | Zhukova, O. B | Biktasova, A. K | Chechina, O. E | Sazonova, E. V | Radzivil, T. T | Wice, A. N | Chasovskikh, N. Yu
The effect of recombinant TNF-α on programmed death of donor lymphocytes was studied in vitro. The proapoptotic effect of this cytokine is realized through transcription factors and cell cycle inhibitors. Incubation of lymphocytes with recombinant TNF-α revealed increased levels of NF-kB and p21 and reducted content of nonphosphorylated p53.
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