Effects of vitamin B12 on cadmium toxicity in rats

Couce, M.D.; Varela, J.M.; Sanchez, A.; Casas, J.S.; Sordo, J.; Lopez-Rivadulla, M.

Effects of vitamin B12 on cadmium toxicity in rats

1991

The survival rate was high among male Sprague rats treated wtih 0.15 mg/kg vitamin B12 (Cyanocobalamine) after injection of 5 mg/kg CdCl2-H2O (LD50). The cadmium content of the liver and, for some protocols, in the kidney was significantly reduced in survivors. According to UV-V and multinuclear (1H, 13C, 31P, and 113Cd) magnetic resonance spectroscopy no direct interaction seems to take place between cyanocobalamine and CdCl2 in aqueous solution at pH 4.5. An indirect mechanism is put forward to explain the antidotal activity.

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AGROVOC Keywords

animals cadmium cadmium interactions kidneys liver liver metabolism methods pharmacokinetics pharmacology rats rats rats tissue distribution toxicity vitamin b12

Bibliographic information

Published in

Journal of inorganic biochemistry

Volume 41 Issue 1 Pagination 1 - 6 ISSN 0162-0134

Other Subjects

Therapeutics; Magnetic resonance spectroscopy; Vitamin b 12; Cadmium chloride; Inbred strains; Kidney; Male; Lethal dose 50; Drug effects

Language

English

Type

Journal Article; Text

In AGRIS since: 2024-02-29

Format: MODS

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Effects of vitamin B12 on cadmium toxicity in rats

1991

AGROVOC Keywords

Bibliographic information