Metal-free regioselective hydrobromination of alkynes through CH/CBr activation
2014
Chen, Xiuling | Chen, Tieqiao | Xiang, Yuqiang | Zhou, Yongbo | Han, Daoqing | Han, Li-Biao | Yin, Shuang-Feng
A metal-free regioselective hydrobromination of alkynes has been developed to provide the Markovnikov-type vinyl bromides in good yields using dibromomethane/N,N-dimethylaniline as in-situ ‘HBr’ source. This protocol also represents an elegant example of the activation of sp² CH and CBr bonds in one pot, in which ‘HBr’ is generated and transferred under mild metal-free conditions. D-incorporated experiments were employed to investigate the reaction mechanism and a plausible reaction path was proposed.
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