Dietary soya protein concentrate enriched with isoflavones reduced fatty liver, increased hepatic fatty acid oxidation and decreased the hepatic mRNA level of VLDL receptor in obese Zucker rats

Gudbrandsen, O.A.; Wergedahl, H.; Mork, S.; Liaset, B.; Espe, M.; Berge, R.K.

Dietary soya protein concentrate enriched with isoflavones reduced fatty liver, increased hepatic fatty acid oxidation and decreased the hepatic mRNA level of VLDL receptor in obese Zucker rats

2006

Casein-based diets containing a low (LDI) or high (HDI) dose of soya protein concentrate enriched with isoflavones were fed to obese Zucker rats for 6 weeks. HDI feeding, but not LDI feeding, reduced the fatty liver and decreased the plasma levels of alanine transaminase and aspartate transaminase. This was accompanied by increased activities of mitochondrial and peroxisomal β-oxidation, acetyl-CoA carboxylase, fatty acid synthase and glycerol-3-phosphate acyltransferase in liver and increased triacylglycerol level in plasma. The decreased fatty liver and the increased plasma triacylglycerol level appeared not to be caused by an increased secretion of VLDL, as HDI decreased the hepatic mRNA levels of apo B and arylacetamide deacetylase. However, the gene expression of VLDL receptor was markedly decreased in liver, but unchanged in epididymal white adipose tissue and skeletal muscle of rats fed HDI, indicating that the liver may be the key organ for the reduced clearance of triacylglycerol-rich lipoproteins from plasma after HDI feeding. The n-3/n-6, 20 : 4n-6/18 : 2n-6 and (20 : 5n-3+22 : 6n-3)/18 : 3n-3 ratios were increased in liver triacylglycerol by HDI. The phospholipids in liver of rats fed HDI contained a low level of 20 : 4n-6 and a high level of 20 : 5n-3, favouring the production of anti-inflammatory eicosanoids. When obese Zucker rats were fed soya protein, this also resulted in reduced fatty liver, possibly through reduced clearance of VLDL by the liver. We conclude that the isoflavone-enriched soya concentrate as well as soya protein may be promising dietary supplements for treatment of non-alcoholic fatty liver.

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AGROVOC Keywords

adipose tissue animals biosynthesis diet therapy dietary supplements dietary supplements enzyme activity etiology fatty acids fatty acids fatty liver fatty liver gene expression regulation genetics isoflavones isoflavones lipid metabolism lipid peroxidation liver liver messenger rna metabolism methods obesity obesity protein concentrates rats rats rats receptors receptors rna soy protein triacylglycerols zucker

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Published in

British journal of nutrition

Volume 96 Issue 2 Pagination 249 - 257 ISSN 0007-1145

Other Subjects

Fatty-acid synthase; Complications; Animal disease models; Ldl; Alanine transaminase; Messenger; Glycerol-3-phosphate acyltransferase; Blood chemistry; Acetyl-coa carboxylase; Very low density lipoprotein; Oxidation-reduction; Therapeutic use; Reverse transcriptase polymerase chain reaction; Male; Soybean proteins; Diet and diet-related diseases; Aspartate transaminase; Physiology of human nutrition; Drug effects

Language

English

Type

Journal Article; Text

In AGRIS since: 2024-02-29

Format: MODS

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Dietary soya protein concentrate enriched with isoflavones reduced fatty liver, increased hepatic fatty acid oxidation and decreased the hepatic mRNA level of VLDL receptor in obese Zucker rats

2006

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