Lipogenesis "in vivo" in lean and genetically obese (ob/ob) mice fed on diets with a high fat content
1979
Cawthorne, M.A. | Cornish, Sharon
The effect of variations in the fat content of the diet on fatty acid synthesis in vivo was determined in lean and genetically obese mice. When lean mice were given a high fat (low-carbohydrate) diet, the rate of lipogenesis in adipose tissue and rest of carcass was less than in similar mice given a high-carbohydrate (low-fat) diet. In obese mice, the rate of lipogenesis in adipose tissue and rest of carcass was unaffected, but liver fatty acid synthesis was reduced. Additional findings are reported. The hyperinsulinemia in obese mice may be able to overcome the inhibitory effect of dietary fat on fatty acid synthesis.
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