Factors influencing the formation of new human coronary lesions: age, blood pressure, and blood cholesterol
1991
Mack, W.J. | Blankenhorn, D.H.
Background. The Cholesterol Lowering Atherosclerosis Study, a controlled angiographic trial, has reported that new native coronary artery lesions are significantly reduced by aggressive blood lipid lowering therapy with colestipol plus niacin. To study factors relevant to primary atherosclerosis prevention, we have conducted an epidemiologic analysis of new native coronary lesion formation in placebo-treated patients. Methods. Univariate and multivariate logistic regression procedures were used to examine age at entry into the study, number of years since bypass, body weight, diastolic and systolic blood pressure, plasma total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, non-HDL-cholesterol, and apolipoproteins A-I, B, and C-III. Results. Significant univariate protective factors were older age (P<.006), reduction of total plasma cholesterol (P<.040), and systolic (P<.024) and diastolic (P<.022) blood pressure. Significant multivariate protective factors were older age (P<.005) and reduction in systolic blood pressure (P<.021). Blood pressure effect were not associated with use of specific antihypertensive agents. Conclusions. These data provide additional support for the control of hypertension and reduction of blood cholesterol level for primary and secondary ischemic heart disease prevention. They also indicate the existence of a population at high risk for early coronary lesion formation and the need for improved means to identify such individuals prior to the onset of clinical manifestations of ischemic heart disease.
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