An Expedient Synthesis of α,α-Difluoro-β-hydroxy Ketones via Decarboxylative Aldol Reaction of α,α-Difluoro-β-keto Acids with Aldehydes
2017
Huang, Da-Kang | Lei, Zhong-Liang | Zhu, Yu-Jun | Liu, Zhen-Jiang | Hu, Xiao-Jun | Mao, Hai-Fang
A novel decarboxylative aldol reaction of α,α-difluoro-β-keto acids with aldehydes in the absence of any base and metal catalysts has been developed. This reaction provides a highly convenient and efficient method for the synthesis of structurally diverse α,α-difluoro-β-hydroxy ketones in good to excellent yields.
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