Relationship between the sulfur content of total parenteral nutrition and sulfoester excretion in low-birthweight infants
1988
Cole, D.E.C. | McPhee, M.D. | Zlotkin, S.H.
Extract: Inorganic sulfate is an end product of sulfur amino acid metabolism but it is also the cosubstrate for the biosynthesis of a wide array of complex sulfoesters. In vitro studies have shown that SO(4) availability may be the primary determinant of sulfoconjugation rates for specific substrates but the relationship between S intake and sulfoester formation in vivo is not known. By substituting MgCl2 for MgSO(4) in an amino acid infusate for parenteral nutrition, we were able to examine prospectively the effect of an altered SO(4) load on S metabolism. In comparing 21 low-birthweight infants on the experimental MgCl2 infusate with 14 subjects on the control MgSO(4) infusate, we observed a 40% decrease in urinary excretion of free SO(4) and a 31% decrease in excretion of total acid-labile sulfoesters. There was a significant correlation (r = 0.44; p less than 0.02) between total S intake and sulfoester excretion, suggesting that S intake influences sulfoconjugation in the low-birthweight infant requiring total parenteral nutrition.(author)
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