Morphology transition of self-aggregates of poly(amino acid)-drug conjugates
2016
Park, Chan Woo | Yang, Hee-Man | Seo, Bum-Kyoung | Kim, Jong-Duk
In this paper, we report morphology tunable self-aggregates of poly(amino acid)-drug conjugates. Amphiphilic drug-grafted polymers were synthesized by grafting hydrophobic phytosphingosine (PHS) onto two different hydrophilic poly(amino acid)s backbones, and the hydrophilic/hydrophobic ratio were controlled by varying the number of grafted drugs. The amphiphilic poly(amino acid)-g-PHS formed self-aggregates in aqueous solution, and morphology transitions of the self-aggregates from sphere to ellipsoid to cylindrical micelles were observed with increasing number of grafted phytosphingosines. Morphologies of self-aggregates were further confirmed by small angle neutron scattering, showing that the obtained self-aggregates consisted of a thin poly(amino acid) shell and a PHS core. The morphological changes of PHS-grafted poly(amino acid) were interpreted using geometrical changes of building blocks arising from the decrease of the hydrophilic part per PHS with increasing number of PHS grafts.
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