Chemical constituents from the fruits of Illicium simonsii and their antiviral activity and neuroprotective effect
2022
Su, Guo-Zhu | Li, Mi | Wang, Xiao-Jing | Wang, Ru-Bing | Ma, Shuang-Gang | Zhang, Dan | Wang, Xiao-Liang | Li, Li | Liu, Yun-Bao | Qu, Jing | Li, Yu-Huan | Li, Yong | Yu, Shi-Shan
One undescribed diterpenoid illisimonone A, four undescribed sesquiterpenes named (±)-simonones A, simonterpenoids A and B, and two undescribed lignans, illisimonins A and B, along with five known compounds were isolated from the fruits of Illicium simonsii. Their structures were elucidated by extensive spectroscopic data. The absolute configuration of illisimonone A was determined by single-crystal X-ray diffraction analysis. Illisimonone A showed potential antiviral activity against the Coxsackie B3 virus, with an IC₅₀ value of 3.70 μM. Illisimonin B and henrylactone A showed potential neuroprotective effects against oxygen-glucose deprivation induced cell injury in SK-N-SH cells, with survival rates of 57.6%, 58.0%, respectively.
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