Two New Benzo[C]Azepin-1-Ones from Whole Plants of Thalictrum glandulosissimum and their Antibacterial Activity
2022
Zhou, Tao | Gao, Qian | Mi, Qi-Li | Yang, Feng-Xian | Wu, Fan | Zhu, Ya-Ning | Liu, Lu | Li, Jing | Liu, Xin | Kong, Wei-Song | Yang, Guang-Yu | Hu, Qiu-Fen | Li, Xue-Mei
Two new benzo[c]azepin-1-ones, 2,3-dihydro-8-(3-hydroxypropyl)-4-methoxy-7-methylbenzo[c]azepin-1- one (1) and 2,3-dihydro-6-(hydroxymethyl)-8-(3-hydroxypropyl)-4-methoxybenzo[c]azepin-1-one (2), were isolated from the whole plants of Thalictrum glandulosissimum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their antibacterial activity. The results showed that both compounds had high antibacterial activity against 12 microbial strains isolated from the saliva of smokers.
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