Porcine synapsin 1: SYN1 gene analysis and functional characterization of the promoter
2013
Hedegaard, Claus | Kjaer-Sorensen, Kasper | Madsen, Lone Bruhn | Henriksen, Carina | Momeni, Jamal | Bendixen, Christian | Oxvig, Claus | Larsen, Knud
Synapsin 1 (SYN1) is a phosphoprotein involved in nerve signal transmission. The porcine SYN1 promoter orthologue was cloned and characterized to provide a means of expressing a transgene specifically in neurons. The nucleotide sequence of the promoter displayed a high degree of conservation of elements responsible for neuron-specific expression. Expression analysis of SYN1 demonstrated presence of transcript during embryonic development. Analysis of GFP expression in transgenic zebrafish embryos suggests that the pig SYN1 promoter directs expression in neuronal cells. Thus, the SYN1 promoter is a good candidate for use in the generation of pig models of human neurodegenerative disorders.
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