Thermosensitive methyl cellulose-based injectable hydrogels for post-operation anti-adhesion
2014
Zhang, Yongli | Gao, Chunjuan | Li, Xiulan | Xu, Chen | Zhang, Yang | Sun, Zhiming | Liu, Yu | Gao, Jianping
Thermosensitive methyl cellulose (MC)-based injectable hydrogels for post-operation anti-adhesion were prepared by integrating polyethylene glycol (PEG), carboxymethyl cellulose (CMC) and chitosan sulfate (CS-SO₃) with MC sols. The viscosity of the MC-based sols depended on the sol composition, especially the amount of CMC. The gelation temperature of the sols was tuned by adjusting the concentrations of K⁺ and other components to obtain an MC-based sol that transformed to a gel at body temperature. The composition of the sol also affected the gel strength. Adding PEG decreased the repulsions between the CMC and CS-SO₃ macromolecules and thus increased the gel strength. The efficacy of the MC-based injectable hydrogels as barriers for reducing postsurgical adhesions was evaluated using a rat cecal abrasion model. The PEG and CS-SO₃ loaded MC-based injectable hydrogels were effective in reducing adhesion formation and reduced adhesiolysis difficulties.
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