Role of Reactive Oxygen Species and Bcl-2 Family Proteins in TNF-α-Induced Apoptosis of Lymphocytes
2010
Ryazanceva, N. V | Novickiy, V. V | Zhukova, O. B | Biktasova, A. K | Chechina, O. E | Sazonova, E. V | Belkina, M. V | Chasovskih, N. Yu | Khaitova, Z. K
We studied the in vitro apoptosis-inducing effect of recombinant TNF-α (rTNF-α) on blood lymphocytes from healthy donors. rTNF-α-induced apoptosis was accompanied by an increase in the number of cells with low mitochondrial transmembrane potential, increased intracellular content of reactive oxygen species, reduced content of Bcl-2, Bcl-xL, and Bax proteins, and elevated Bad content. The molecular mechanisms of these changes are discussed.
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