Determination of gadoliniumâbased magnetic resonance imaging contrast agents by micellar electrokinetic capillary chromatography
2011
Andrási, Melinda | Gáspár, Attila | Kovács, Otilia | Baranyai, Zsolt | Klekner, Ãlmos | Brücher, Ernő
MEKC with DAD was applied to detect six Gdâbased contrasting agents (CAs) (GdâDTPAâBMA (Omniscan), GdâHPDO3A (ProHance), GdâDOTA (Dotarem), GdâAAZTA, GdâBOPTA (Multihance) and GdâDTPA (Magnevist)) commonly used in MRI diagnostics. The achieved LODs ranged between 0.40 and 20âμM and the optimized method gave excellent precision, especially when two internal standards were applied (less than 0.34 RSD% for migration time). The MEKC technique made it possible to determine the CAs in urine and serum samples of patients having a therapeutic dose. Due to the SDS content of the running buffer, the serum samples can be directly injected to analyze Gdâbased CAs without interference of high protein content.
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by National Agricultural Library