Effects of essential fatty acid deficiency, and various levels of dietary polyunsaturated fatty acids, on humoral immunity in mice
1979
DeWille, James W. | Fraker, Pamela J. | Romsos, Dale R.
Six experiments determined the influence of an essential fatty acid deficient diet (EFAD), and various levels of dietary polyunsaturated fatty acids, on humoral immunity in mice. Consumption of diets deficient in essential fatty acids (0% corn oil) significantly reduced the humoral response after 28 days; this preceded the effects of the EFAD diet on growth or appearance. Reduced antibody response was demonstrated against T-cell dependent and independent antigens, and in both primary and secondary responses of mice fed the EFAD diet. After 56 days of feeding the EFAD diet, mice switched to the control diet of 13% corn oil for 7 days demonstrated full recovery of the humoral response. Diets containing from 2 to 70% of energy from corn oil did not adversely affect th humoral response. It is concluded that essential fatty acids play a crucial role in maintaining the functional integrity of humoral immunity.
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