Antioxidative photochemoprotector effects of cerium oxide nanoparticles on UVB irradiated fibroblast cells
2020
Peloi, Karen E. | Contreras Lancheros, César A. | Nakamura, Celso V. | Singh, Sushant | Neal, Craig | Sakthivel, Tamil S. | Seal, Sudpita | Lautenschlager, Suelide Oliveira Silva
The Ultraviolet-B radiation (UVB) might induce cellular redox imbalance which plays an important role in the development of skin disorders. Thus, the search for photochemoprotective alternatives with antioxidant efficacy would be a safe aspect towards prevention of skin diseases. Cerium oxide nanoparticles (CNPs) have antioxidant properties, that are mostly related to CNPs catalase and superoxide dismutase (SOD)-like antioxidative mimetic activity. Considering that, we investigated whether CNPs induce photochemoprotection against UVB-induced cellular damages on L929 fibroblasts. Our results showed that CNPs prevented UVB mediated L929 cell oxidative damage by reestablishing the oxidative balance through ameliorating the reactive oxygen species (ROS) level and enhancing the antioxidant enzyme activities.
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