The influence of early nutrition on the serum cholesterol of the adult rat
1979
Kris-Etherton, P.M. | Layman, Donald K. | York, Pamela VanZyl | Frantz, Ivan D. Jr
Using five different postnatal diets followed by a cholesterol challenge diet in adult life, the effects of infant nutrition on adult serum cholesterol in rats are discussed. The five infant-adult diets were: one, nursing from dams with high cholesterol milk followed by a stock diet supplemented with 10% lard and 0.5% cholesterol; two, receiving 10 mg cholesterol dissolved in 0.5 ml of corn oil followed by the same supplemented stock diet; three, a cholesterol free formula followed by the same supplemented stock diet for one month; four, the cholesterol free formula plus 50% cholesterol with the same ensuing one month regimen; and five, normally suckled pups with the ensuing one month regimen. In diets one and two, there was no protection against dietary induced hypercholesterolemia in adult life; in fact, all experiments relate the notion that early dietary cholesterol exposure protects against adult hypercholesterolemia. However, artificially reared rats have a decreased ability to handle a cholesterol challenge.
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