The Role of Mitochondrial DNA Individuality in the Pathogenesis of Parkinson’s Disease
2020
Sukhorukov, V. S. | Voronkova, A. S. | Litvinova, N. A. | Baranich, T. I. | Illarioshkin, S. N.
The present article reviews the rapidly growing body of research on the role of mitochondrial DNA (mtDNA) in the realization of individual risk of Parkinson’s disease. In this context, inherited mtDNA mutations, variants of its de novo polymorphism, haplogroup polymorphism, and accumulation of the mitochondrial genome somatic mutations are considered separately. Analysis of the reviewed published data shows that, at the moment, the haplogroup features and the mtDNA copy number should be considered the most proven risk factors for Parkinson’s disease. Data on similar importance of the mtDNA somatic mutations, its hereditary variants, and de novo mutations remain controversial and require careful study, primarily in animal and cell models.
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