Experimental food allergy leads to adipose tissue inflammation, systemic metabolic alterations and weight loss in mice
2011
Dourado, Luana Pereira Antunes | Noviello, Maria de Lourdes Meirelles | Alvarenga, Débora Moreira | Menezes, Zélia | Perez, Denise Alves | Batista, Nathália Vieira | Menezes, Gustavo Batista | Ferreira, Adaliene Versiani Matos | Souza, Danielle da Glória de | Cara, Denise Carmona
To investigate the consequences of food allergy in adipose tissue and metabolism, we used a murine model in which mice have been sensitized subcutaneously with ovalbumin and further received antigen-containing diet. Allergic mice presented a significant weight loss 7days after oral challenge with a concomitant decrease in epididymal adipose tissue mass. This decrease was associated with increased lipolysis and local inflammation. In adipose tissue of allergic mice there were increased leukocyte rolling and adhesion in the microvasculature, increased number of leukocytes in the tissue, especially macrophages (F4/80⁺ cells) and increased pro-inflammatory cytokines levels, including TNF-α, IL-6 and CCL2. In addition, we observed low serum concentrations of triglyceride, glucose, total cholesterol and free fatty acids in the allergic mice. Our results suggest that the induction of food allergy in mice leads to adipose tissue inflammation and systemic metabolic alterations that contribute to the weight loss observed.
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by National Agricultural Library