Peripheral natural killer cell activity as a predictor of recurrent pregnancy loss: a large cohort study
2013
Katano, Kinue | Suzuki, Sadao | Ozaki, Yasuhiko | Suzumori, Nobuhiro | Kitaori, Tamao | Sugiura-Ogasawara, Mayumi
OBJECTIVE: To determine the predictive value of preconceptional peripheral blood natural killer (pNK) cell activity in patients with recurrent pregnancy loss (RPL). DESIGN: Cohort study. SETTING: University department. PATIENT(S): A total of 552 patients with a history of two to six consecutive miscarriages. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The predictive value of preconceptional pNK cell activity for subsequent miscarriage was analyzed using multivariable logistic regression analysis, with age, number of previous miscarriages, and presence/absence of previous live births and bed rest as covariates. RESULT(S): Age and number of previous miscarriages, but not high pNK cell activity, were found to be independent risk factors for a subsequent miscarriage. No effect of bed rest and previous live birth on the likelihood of live birth was observed (odds ratios 1.28 [95% confidence interval 0.81–2.02] and 0.91 [0.52–1.59], respectively). CONCLUSION(S): Elevated pNK cell activity was found to not be an independent risk factor for subsequent miscarriage. Clinicians should not measure the plasma NK activity as a systematic recurrent pregnancy loss examination, because its clinical significance is yet to be established.
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