Trace elements in the elderly
1989
Prasad, A.S.
Amongst the trace elements, only iron, iodine, zinc, copper, chromium, selenium, managanese, cobalt and fluoride are considered to be essential for human health. In general, little is known concerning the metabolic effects of aging on trace elements. It has been hypothesized that a marginal deficiency of zinc and chromium may develop with advancing age. Decreased dietary intake of zinc and a decline in plasma zinc have been observed in elderly subjects. In view of the known effects of zinc on protein synthesis, gonadal functions in males and cell mediated immunity, it is reasonable to speculate that decreased testosterone levels, problems with wound healing, and anergy so commonly seen in elderly subjects may be related to a marginal deficiency of zinc. Adult onset diabetes may be related to a deficiency of chromium inasmuch as chromium is essential for glucose metabolism and a decline in chromium content of tissues has been reported in elderly subjects. Whether or not a decreased intake of copper plays a role in atherosclerosis and increased aluminum intake is related to Alzheimer's disease remains to be settled.
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